Optogenetic Switches
UV
Violet
Blue
Cyan
Green
Yellow
Red
Far Red
300 nm
400 nm
500 nm
600 nm
700 nm
- UV receptors
- BLUF domains
- LOV domains
- Cryptochromes
- Fluorescent proteins
- Cobalamin-binding domains
- Phytochromes
UV receptors
- Switch name (# of implementations)
- Mode of action
- UVR8/COP1 (4)
- heterodimerization
- UVR8/UVR8 (3)
- homodimerization, dissociation
BLUF domains
- Switch name (# of implementations)
- Mode of action
- PixD/PixE (4)
- heterooligomerization, dissociation
LOV domains
- Switch name (# of implementations)
- Mode of action
- AsLOV2 (182)
- intramolecular conformational change
- iLID (152)
- heterodimerization
- LOVTRAP (45)
- heterodimerization, dissociation
- TULIP (35)
- heterodimerization
- AtLOV2 (10)
- intramolecular conformational change
- BcLOV4 (12)
- intramolecular conformational change, membrane recruitment
- cpLOV2 (7)
- intramolecular conformational change
- cpLID (1)
- heterodimerization
- cpLOVTRAP (2)
- heterodimerization, dissociation
- CrLOV1 (3)
- ? Add information
- EL222 (64)
- homodimerization, DNA binding
- FKF1/GI (11)
- heterodimerization
- NcWC1-LOV (5)
- ? Add information
- PAL (11)
- RNA aptamer binding, translation control
- PtAU1-LOV (5)
- homodimerization
- RsLOV (7)
- homodimerization, dissociation
- VfAU1-LOV (26)
- homodimerization
- VVD (73)
- homodimerization
- Magnets (69)
- heterodimerization
- YtvA (40)
- homodimerization
- miniSOG (13)
- singlet oxygen (ROS) production
- mPAC (2)
- cAMP production
Cryptochromes
- Switch name (# of implementations)
- Mode of action
- CRY2/CIB1 (304)
- heterodimerization
- CRY2/CRY2 (118)
- homooligomerization
- CRY2clust (20)
- homooligomerization
- CRY2high (1)
- homooligomerization
- CRY2low (2)
- homooligomerization
- CRY2olig (70)
- homooligomerization
Fluorescent proteins
- Switch name (# of implementations)
- Mode of action
- Dronpa145K/N (4)
- heterodimerization, dissociation
- Dronpa145N (4)
- homotetramerization, dissociation
- pdDronpa1 (8)
- homodimerization, dissociation
- PhoCl (17)
- photocleavage
- PYP (7)
- intramolecular conformational change
Cobalamin-binding domains
- Switch name (# of implementations)
- Mode of action
- MxCBD (2)
- homotetramerization, dissociation
- TtCBD (15)
- homotetramerization, dissociation
Phytochromes
- Switch name (# of implementations)
- Mode of action
- Am1 c0023g2 (0)
- not a switch, only parental photoreceptor
- BICYCL-Green (1)
- heterodimerization
- BICYCL-Red (1)
- heterodimerization
- BphP1/PpsR2 (7)
- heterodimerization
- BphP1/Q-PAS1 (10)
- heterodimerization
- Cph1 (20)
- homodimerization
- DrBphP (17)
- homodimerization, dissociation
- MagRed (3)
- heterodimerization
- nanoReD (1)
- heterodimerization
- PaaC (1)
- cAMP production
- PagC (1)
- cGMP production
- iLight (3)
- homodimerization
- PhyA/FHY1 & PhyA/FHL (7)
- heterodimerization
- PhyB/PIF3 & PhyB/PIF6 (92)
- heterodimerization
- BphG (2)
- c-di-GMP production
- BphS (26)
- c-di-GMP production
- IlaC (3)
- cAMP production
- IlaM (1)
- cAMP production
- CcaS/CcaR (35)
- gene expression
- cPAC (1)
- cAMP production
- DdPAC (1)
- cAMP production
- DmBphP (1)
- not a switch, only parental photoreceptor
- DmPAC (2)
- cAMP production
- DmPGC (1)
- cGMP production
- LAPD (4)
- cGMP/cAMP hydrolysis
- UirS/UirR (2)
- gene expression