TULIP

Photoreceptor LOVpep (AsLOV2–ePDZpeptide)
Binding partner ePDZ
Cofactor FMN
Source organism Avena sativa
Mode of action heterodimerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time seconds to minutes (variants available)
Add a new 3D structure

Related original publications

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  1. Rationally designed light-inducible RNA-releasing protein for translational regulation and optogenetic control of gene therapies. Trends Biotechnol, 2026
  2. Optogenetic BlueGENEs engineered into a human safe harbor locus. Nucleic Acids Res, 2026
  3. Optogenetic control of biomolecular organization reveals distinct roles of phase separation in RTK signaling. Cell Chem Biol, 2025
  4. Cell cycle oscillations in a polarity network facilitate state switching by morphogenetic cues. bioRxiv, 2025
  5. Neighbor cells restrain furrowing during Xenopus epithelial cytokinesis. Dev Cell, 2025
  6. Genetically-stable engineered optogenetic gene switches modulate spatial cell morphogenesis in two- and three-dimensional tissue cultures. Nat Commun, 2024
  7. Image-guided optogenetic spatiotemporal tissue patterning using μPatternScope. Nat Commun, 2024
  8. Mechanosensitive recruitment of Vinculin maintains junction integrity and barrier function at epithelial tricellular junctions. Curr Biol, 2024
  9. A cytokinetic ring-driven cell rotation achieves Hertwig’s rule in early development. PNAS, 2024
  10. Concept and considerations of a medical device: the active noise cancelling incubator. Front Pediatr, 2023
  11. Engineering of bidirectional, cyanobacteriochrome-based light-inducible dimers (BICYCL)s. Nat Methods, 2023
  12. Polarized branched Actin modulates cortical mechanics to produce unequal-size daughters during asymmetric division. Nat Cell Biol, 2023
  13. Optical regulation of endogenous RhoA reveals selection of cellular responses by signal amplitude. Cell Rep, 2022
  14. Light-inducible deformation of mitochondria in live cells. Cell Chem Biol, 2021
  15. Physically asymmetric division of the C. elegans zygote ensures invariably successful embryogenesis. Elife, 2021
  16. Blue Light‐Operated CRISPR/Cas13b‐Mediated mRNA Knockdown (Lockdown). Adv Biol, 2021
  17. Correction to Lancet Infectious Diseases 2020; published online April 29. https://doi.org/10.1016/ S1473-3099(20)30064-5. Lancet Infect Dis, 2020
  18. RhoA Mediates Epithelial Cell Shape Changes via Mechanosensitive Endocytosis. Dev Cell, 2019
  19. SapTrap Assembly of Caenorhabditis elegans MosSCI Transgene Vectors. G3 (Bethesda), 2019
  20. Mechanosensitive junction remodelling promotes robust epithelial morphogenesis. Lancet Diabetes Endocrinol, 2019
  21. Neurotrophin receptor tyrosine kinases regulated with near-infrared light. Nat Commun, 2019
  22. Guided by light: optogenetic control of microtubule gliding assays. Nano Lett, 2018
  23. Adherens junction-associated pores mediate the intercellular transport of endosomes and cytoplasmic proteins. Biochem Biophys Res Commun, 2018
  24. Optogenetic dissection of mitotic spindle positioning in vivo. Elife, 2018
  25. An Optogenetic approach to control protein localization during embryogenesis of the sea urchin. Dev Biol, 2018
  26. Engaging myosin VI tunes motility, morphology, and identity in endocytosis. Traffic, 2018
  27. Optogenetic interrogation of integrin αVβ3 function in endothelial cells. J Cell Sci, 2017
  28. Cell cycle entry triggers a switch between two modes of Cdc42 activation during yeast polarization. Elife, 2017
  29. Optogenetic control of RhoA reveals zyxin-mediated elasticity of stress fibres. Nat Commun, 2017
  30. A Phytochrome-Derived Photoswitch for Intracellular Transport. ACS Synth Biol, 2017
  31. Transcription activator-like effector-mediated regulation of gene expression based on the inducible packaging and delivery via designed extracellular vesicles. Biochem Biophys Res Commun, 2017
  32. Local RhoA activation induces cytokinetic furrows independent of spindle position and cell cycle stage. J Cell Biol, 2016
  33. Light-controlled intracellular transport in Caenorhabditis elegans. Curr Biol, 2016
  34. Correlating in Vitro and in Vivo Activities of Light-Inducible Dimers: A Cellular Optogenetics Guide. ACS Synth Biol, 2015
  35. Optogenetic control of organelle transport and positioning. Nature, 2015
  36. Benchmarking of optical dimerizer systems. ACS Synth Biol, 2014
  37. Orthogonal optogenetic triple-gene control in Mammalian cells. ACS Synth Biol, 2014
  38. TULIPs: tunable, light-controlled interacting protein tags for cell biology. Nat Methods, 2012
  39. Optogenetic Control of RhoA to Probe Subcellular Mechanochemical Circuitry. Curr Protoc Cell Biol, 2020