Magnets

Photoreceptor pMag, nMag
Binding partner /
Cofactor FAD
Source organism Neurospora crassa
Mode of action heterodimerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time seconds to hours (variants available)

Related original publications

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  1. Engineering an Optogenetic pH-Modulator in Bacteria. Adv Sci (Weinh), 2026
  2. Optimized optogenetic anti-CRISPR for endogenous gene regulation in Drosophila. Nucleic Acids Res, 2026
  3. Light-inducible FLPase reconstitution enables temporal control of gene expression in Drosophila melanogaster. Cell Rep Methods, 2026
  4. Enhancing the performance of Magnets photosensors. Nat Commun, 2026
  5. ShineGAL4 drivers for tissue and cell-type specific optogenetics in Drosophila. Development, 2026
  6. Single-cell characterization of bacterial optogenetic Cre recombinases. iScience, 2026
  7. Optogenetic control of biomolecular organization reveals distinct roles of phase separation in RTK signaling. Cell Chem Biol, 2025
  8. AlphaFold3-guided optimization of a photoactivatable endonuclease for top-down genome engineering. J Biol Chem, 2025
  9. De novo designed protein guiding targeted protein degradation. Nat Commun, 2025
  10. Single-cell characterization of bacterial optogenetic Cre recombinases. bioRxiv, 2025
  11. Digitizing the Blue Light-Activated T7 RNA Polymerase System with a tet-Controlled Riboregulator. ACS Synth Biol, 2025
  12. Multiplexing light-inducible recombinases to control cell fate, Boolean logic, and cell patterning in mammalian cells. Sci Adv, 2025
  13. Engineered depalmitoylases enable selective manipulation of protein localization and function. Nat Commun, 2025
  14. Application of the Magnet-Cre optogenetic system in the chicken model. Dev Biol, 2025
  15. A subcellular map of translational machinery composition and regulation at the single-molecule level. Science, 2025
  16. Complex optogenetic spatial patterning with split recombinase. bioRxiv, 2024
  17. In Vivo Optogenetics Based on Heavy Metal-Free Photon Upconversion Nanoparticles. Adv Mater, 2024
  18. Optogenetic control of early embryos labeling using photoactivatable Cre recombinase 3.0. FEBS Open Bio, 2024
  19. In vivo optogenetic manipulations of endogenous proteins reveal spatiotemporal roles of microtubule and kinesin in dendrite patterning. Sci Adv, 2024
  20. Dynamic Multiplexed Control and Modeling of Optogenetic Systems Using the High-Throughput Optogenetic Platform, Lustro. ACS Synth Biol, 2024
  21. Optogenetic Control of Bacterial Cell-Cell Adhesion Dynamics: Unraveling the Influence on Biofilm Architecture and Functionality. Adv Sci (Weinh), 2024
  22. Programmable RNA base editing with photoactivatable CRISPR-Cas13. Nat Commun, 2024
  23. Photoactivation of LOV domains with chemiluminescence. Chem Sci, 2023
  24. Design and Engineering of Light-Induced Base Editors Facilitating Genome Editing with Enhanced Fidelity. Adv Sci (Weinh), 2023
  25. A programmable protease-based protein secretion platform for therapeutic applications. Nat Chem Biol, 2023
  26. Comprehensive Screening of a Light-Inducible Split Cre Recombinase with Domain Insertion Profiling. ACS Synth Biol, 2023
  27. Spatiotemporal, optogenetic control of gene expression in organoids. Nat Methods, 2023
  28. Photoactivatable base editors for spatiotemporally controlled genome editing in vivo. Biomaterials, 2023
  29. Diya – a universal light illumination platform for multiwell plate cultures. iScience, 2023
  30. High-Throughput Optogenetics Experiments in Yeast Using the Automated Platform Lustro. J Vis Exp, 2023
  31. Opto-RhoGEFs, an optimized optogenetic toolbox to reversibly control Rho GTPase activity on a global to subcellular scale, enabling precise control over vascular endothelial barrier strength. Elife, 2023
  32. Lustro: High-Throughput Optogenetic Experiments Enabled by Automation and a Yeast Optogenetic Toolkit. ACS Synth Biol, 2023
  33. Detecting Photoactivatable Cre-mediated Gene Deletion Efficiency in Escherichia coli. Bio Protoc, 2023
  34. Generation of a photocontrollable recombinant bovine parainfluenza virus type 3. Microbiol Immunol, 2023
  35. Stable Transgenic Mouse Strain with Enhanced Photoactivatable Cre Recombinase for Spatiotemporal Genome Manipulation. Adv Sci (Weinh), 2022
  36. Blue Light Signaling Regulates Escherichia coli W1688 Biofilm Formation and l-Threonine Production. Microbiol Spectr, 2022
  37. Dynamic cybergenetic control of bacterial co-culture composition via optogenetic feedback. Nat Commun, 2022
  38. Implementation of a Novel Optogenetic Tool in Mammalian Cells Based on a Split T7 RNA Polymerase. ACS Synth Biol, 2022
  39. Rapid and robust optogenetic control of gene expression in Drosophila. Dev Cell, 2021
  40. Exploiting Noise, Non-Linearity, and Feedback for Differential Control of Multiple Synthetic Cells with a Single Optogenetic Input. ACS Synth Biol, 2021
  41. Repetitive short-pulsed illumination efficiently activates photoactivatable-Cre as continuous illumination in embryonic stem cells and pre-implantation embryos of transgenic mouse. Genesis, 2021
  42. Optogenetic Tools for Manipulating Protein Subcellular Localization and Intracellular Signaling at Organelle Contact Sites. Curr Protoc, 2021
  43. A single-chain and fast-responding light-inducible Cre recombinase as a novel optogenetic switch. Elife, 2021
  44. Efficient photoactivatable Dre recombinase for cell type-specific spatiotemporal control of genome engineering in the mouse. Proc Natl Acad Sci U S A, 2020
  45. Optimized Vivid-derived Magnets photodimerizers for subcellular optogenetics in mammalian cells. Elife, 2020
  46. Optogenetic regulation of embryo implantation in mice using photoactivatable CRISPR-Cas9. Proc Natl Acad Sci U S A, 2020
  47. Exploiting natural chemical photosensitivity of anhydrotetracycline and tetracycline for dynamic and setpoint chemo-optogenetic control. Nat Commun, 2020
  48. Bioluminescence-Triggered Photoswitchable Bacterial Adhesions Enable Higher Sensitivity and Dual-Readout Bacterial Biosensors for Mercury. ACS Sens, 2020
  49. Photoactivatable Cre recombinase 3.0 for in vivo mouse applications. Nat Commun, 2020
  50. Blue-Light-Switchable Bacterial Cell-Cell Adhesions Enable the Control of Multicellular Bacterial Communities. ACS Synth Biol, 2020
  51. Establishment of a tTA-dependent photoactivatable Cre recombinase knock-in mouse model for optogenetic genome engineering. Biochem Biophys Res Commun, 2020
  52. Light-Inducible Recombinases for Bacterial Optogenetics. ACS Synth Biol, 2020
  53. Engineered BRET-Based Biologic Light Sources Enable Spatiotemporal Control over Diverse Optogenetic Systems. ACS Synth Biol, 2019
  54. The importance of cell-cell interaction dynamics in bottom-up tissue engineering: Concepts of colloidal self-assembly in the fabrication of multicellular architectures. Nano Lett, 2019
  55. High-performance chemical- and light-inducible recombinases in mammalian cells and mice. Nat Commun, 2019
  56. Optogenetic activation of intracellular antibodies for direct modulation of endogenous proteins. Nat Methods, 2019
  57. An AND-Gated Drug and Photoactivatable Cre-loxP System for Spatiotemporal Control in Cell-Based Therapeutics. ACS Synth Biol, 2019
  58. Near-infrared optogenetic genome engineering based on photon upconversion hydrogels. Angew Chem Int Ed Engl, 2019
  59. A split CRISPR-Cpf1 platform for inducible genome editing and gene activation. Nat Chem Biol, 2019
  60. Photocontrollable mononegaviruses. Proc Natl Acad Sci USA, 2019
  61. Noninvasive optical activation of Flp recombinase for genetic manipulation in deep mouse brain regions. Nat Commun, 2019
  62. Reversible Social Self-Sorting of Colloidal Cell-Mimics with Blue Light Switchable Proteins. ACS Synth Biol, 2018
  63. Light-activated protein interaction with high spatial subcellular confinement. Proc Natl Acad Sci USA, 2018
  64. Optogenetic Control of Endoplasmic Reticulum-Mitochondria Tethering. ACS Synth Biol, 2017
  65. Dynamic Blue Light-Inducible T7 RNA Polymerases (Opto-T7RNAPs) for Precise Spatiotemporal Gene Expression Control. ACS Synth Biol, 2017
  66. CRISPR-Cas9-based photoactivatable transcription systems to induce neuronal differentiation. Nat Methods, 2017
  67. Blue Light Switchable Bacterial Adhesion as a Key Step toward the Design of Biofilms. ACS Synth Biol, 2017
  68. Assembly Domain-Based Optogenetic System for the Efficient Control of Cellular Signaling. ACS Synth Biol, 2017
  69. Engineered Photoactivatable Genetic Switches Based on the Bacterium Phage T7 RNA Polymerase. ACS Synth Biol, 2016
  70. Optical manipulation of the alpha subunits of heterotrimeric G proteins using photoswitchable dimerization systems. Sci Rep, 2016
  71. A photoactivatable Cre-loxP recombination system for optogenetic genome engineering. Nat Chem Biol, 2016
  72. Photoactivatable CRISPR-Cas9 for optogenetic genome editing. Nat Biotechnol, 2015
  73. Engineered pairs of distinct photoswitches for optogenetic control of cellular proteins. Nat Commun, 2015
  74. Optical Control of Genome Editing by Photoactivatable Cas9. Methods Mol Biol, 2021
  75. Optogenetic Activation of Intracellular Nanobodies. Methods Mol Biol, 2022
  76. Engineered Cas9 extracellular vesicles as a novel gene editing tool. J Extracell Vesicles, 2022
  77. Optical Control of Mononegavirus Gene Expression and Replication. Methods Mol Biol, 2024