EL222

Related original publications

1. Light-directed evolution of dynamic, multi-state, and computational protein functionalities. Cell, 2026
2. Improving T cell expansion by optogenetically engineered bacteria-loaded MMP-2-responsive cyclophosphamide for antitumor immunotherapy. J Nanobiotechnology, 2025
3. Magneto-Photonic Gene Circuit for Minimally Invasive Control of Gene Expression in Mammalian Cells. bioRxiv, 2025
4. De novo designed protein guiding targeted protein degradation. Nat Commun, 2025
5. Potent optogenetic regulation of gene expression in mammalian cells for bioproduction and basic research. Nucleic Acids Res, 2025
6. Orthogonal replication with optogenetic selection evolves yeast JEN1 into a mevalonate transporter. Mol Syst Biol, 2025
7. Balancing Doses of EL222 and Light Improves Optogenetic Induction of Protein Production in Komagataella phaffii. Biotechnol Bioeng, 2025
8. Optogenetic control of pheromone gradients and mating behavior in budding yeast. Life Sci Alliance, 2025
9. Light-induced expression of gRNA allows for optogenetic gene editing of T lymphocytes in vivo. Nucleic Acids Res, 2025
10. Anti-Pdc1p Nanobody as a Genetically Encoded Inhibitor of Ethanol Production Enables Dual Transcriptional and Post-translational Controls of Yeast Fermentations. ACS Synth Biol, 2025
11. Light-induced programmable solid-liquid phase transition of biomolecular condensates for improved biosynthesis. Trends Biotechnol, 2025
12. Functional analysis of Saccharomyces cerevisiae FLO genes through optogenetic control. FEMS Yeast Res, 2025
13. Optogenetic control of transgene expression in Marchantia polymorpha. Appl Plant Sci, 2025
14. Optogenetic control of Corynebacterium glutamicum gene expression. Nucleic Acids Res, 2024
15. Genetically-stable engineered optogenetic gene switches modulate spatial cell morphogenesis in two- and three-dimensional tissue cultures. Nat Commun, 2024
16. Light-Induced Nanobody-Mediated Targeted Protein Degradation for Metabolic Flux Control. ACS Synth Biol, 2024
17. Bacteria-based cascade in situ near-infrared nano-optogenetically induced photothermal tumor therapy. Theranostics, 2024
18. Optogenetic control of phosphate-responsive genes using single component fusion proteins in Saccharomyces cerevisiae. bioRxiv, 2024
19. Multisite Assembly of Gateway Induced Clones (MAGIC): a flexible cloning toolbox with diverse applications in vertebrate model systems. bioRxiv, 2024
20. Dynamic Multiplexed Control and Modeling of Optogenetic Systems Using the High-Throughput Optogenetic Platform, Lustro. ACS Synth Biol, 2024
21. Multicolor optogenetics for regulating flux ratio of three glycolytic pathways using EL222 and CcaSR in Escherichia coli. Biotechnol Bioeng, 2023
22. Light induced expression of gRNA allows for optogenetic gene editing of T lymphocytes in vivo. bioRxiv, 2023
23. Diya – a universal light illumination platform for multiwell plate cultures. iScience, 2023
24. Multidimensional characterization of inducible promoters and a highly light-sensitive LOV-transcription factor. Nat Commun, 2023
25. A Bioluminescent Activity Dependent (BLADe) Platform for Converting Neuronal Activity to Photoreceptor Activation. bioRxiv, 2023
26. Optogenetic closed-loop feedback control of the unfolded protein response optimizes protein production. Metab Eng, 2023
27. Light inducible protein degradation in E. coli with LOVtag. bioRxiv, 2023
28. Optogenetic control of beta-carotene bioproduction in yeast across multiple lab-scales. Front Bioeng Biotechnol, 2023
29. Near-Infrared Nano-Optogenetic Activation of Cancer Immunotherapy via Engineered Bacteria. Adv Mater, 2022
30. A Single-Component Blue Light-Induced System Based on EL222 in Yarrowia lipolytica. Int J Mol Sci, 2022
31. Hydrogel microcapsules containing engineered bacteria for sustained production and release of protein drugs. Biomaterials, 2022
32. Synthetic cells with self-activating optogenetic proteins communicate with natural cells. Nat Commun, 2022
33. Synthetic gene networks recapitulate dynamic signal decoding and differential gene expression. Cell Syst, 2022
34. Using single-cell models to predict the functionality of synthetic circuits at the population scale. Proc Natl Acad Sci U S A, 2022
35. Systematic In Vivo Characterization of Fluorescent Protein Maturation in Budding Yeast. ACS Synth Biol, 2022
36. Development of Optogenetic Dual-Switch System for Rewiring Metabolic Flux for Polyhydroxybutyrate Production. Molecules, 2022
37. Design and Characterization of an Optogenetic System in Pichia pastoris. ACS Synth Biol, 2022
38. A light tunable differentiation system for the creation and control of consortia in yeast. Nat Commun, 2021
39. Rapid prototyping and design of cybergenetic single-cell controllers. Nat Commun, 2021
40. Light-Induced GFP Expression in Zebrafish Embryos using the Optogenetic TAEL/C120 System. J Vis Exp, 2021
41. The Neurospora crassa Inducible Q System Enables Simultaneous Optogenetic Amplification and Inversion in Saccharomyces cerevisiae for Bidirectional Control of Gene Expression. ACS Synth Biol, 2021
42. Cellulosic biofuel production using emulsified simultaneous saccharification and fermentation (eSSF) with conventional and thermotolerant yeasts. Biotechnol Biofuels, 2021
43. Engineered NIR light-responsive bacteria as anti-tumor agent for targeted and precise cancer therapy. Lancet Infect Dis, 2021
44. Optogenetic Amplification Circuits for Light-Induced Metabolic Control. ACS Synth Biol, 2021
45. Blue Light‐Operated CRISPR/Cas13b‐Mediated mRNA Knockdown (Lockdown). Adv Biol, 2021
46. TAEL 2.0: An Improved Optogenetic Expression System for Zebrafish. Zebrafish, 2021
47. Dynamical Modeling of Optogenetic Circuits in Yeast for Metabolic Engineering Applications. ACS Synth Biol, 2021
48. Optogenetics in Sinorhizobium meliloti Enables Spatial Control of Exopolysaccharide Production and Biofilm Structure. ACS Synth Biol, 2021
49. An Optogenetic Platform to Dynamically Control the Stiffness of Collagen Hydrogels. ACS Biomater Sci Eng, 2020
50. Engineering an Optogenetic CRISPRi Platform for Improved Chemical Production. ACS Synth Biol, 2020
51. An Irf6-Esrp1/2 regulatory axis controls midface morphogenesis in vertebrates. Development, 2020
52. Design and Characterization of Rapid Optogenetic Circuits for Dynamic Control in Yeast Metabolic Engineering. ACS Synth Biol, 2020
53. Optogenetic Downregulation of Protein Levels to Control Programmed Cell Death in Mammalian Cells with a Dual Blue-Light Switch. Methods Mol Biol, 2020
54. Optogenetic control of gene expression in plants in the presence of ambient white light. Nat Methods, 2020
55. Light-powered Escherichia coli cell division for chemical production. Nat Commun, 2020
56. Blue Light-Directed Cell Migration, Aggregation, and Patterning. J Mol Biol, 2020
57. Optical induction of autophagy via Transcription factor EB (TFEB) reduces pathological tau in neurons. PLoS ONE, 2020
58. Cell-in-the-loop pattern formation with optogenetically emulated cell-to-cell signaling. Nat Commun, 2020
59. An Open-Source Plate Reader. Biochemistry, 2018
60. Programming the Dynamic Control of Bacterial Gene Expression with a Chimeric Ligand- and Light-Based Promoter System. ACS Synth Biol, 2018
61. Dual-controlled optogenetic system for the rapid down-regulation of protein levels in mammalian cells. Sci Rep, 2018
62. Pulsatile inputs achieve tunable attenuation of gene expression variability and graded multi-gene regulation. Nat Commun, 2018
63. An Optogenetic Platform for Real-Time, Single-Cell Interrogation of Stochastic Transcriptional Regulation. Mol Cell, 2018
64. Cell-free optogenetic gene expression system. ACS Synth Biol, 2018
65. Optogenetic regulation of engineered cellular metabolism for microbial chemical production. Nature, 2018
66. A calcium- and light-gated switch to induce gene expression in activated neurons. Nat Biotechnol, 2017
67. TAEL: a zebrafish-optimized optogenetic gene expression system with fine spatial and temporal control. Development, 2016
68. Blue light-mediated transcriptional activation and repression of gene expression in bacteria. Nucleic Acids Res, 2016
69. An optogenetic gene expression system with rapid activation and deactivation kinetics. Nat Chem Biol, 2014
70. Blue light-induced dimerization of a bacterial LOV-HTH DNA-binding protein. Biochemistry, 2013
71. Blue light-mediated gene expression as a promising strategy to reduce antibiotic resistance in Escherichia coli. Biotechnol J, 2024
72. Construction and Characterization of Light-Responsive Transcriptional Systems. Methods Mol Biol, 2024