EL222

Related original publications

1. Ingestible Hydrogel-Encapsulated Optogenetic Yeast Controlled by Wearable Electronics Enables Programmable IL-10 Delivery for Inflammatory Bowel Disease Therapy. ACS Appl Mater Interfaces, 2026
2. Rapid and reversible regulation of cell cycle progression in budding yeast using optogenetics. Cell Rep Methods, 2026
3. Multi-level precise regulation of gene transcription in the yeast Saccharomyces cerevisiae based on light-sensitive CRISPR/Cas systems. Nucleic Acids Res, 2026
4. Dual-channel optogenetics in yeast for multiplexed light-based control of cellular processes and pathways. Nat Commun, 2026
5. Rationally designed light-inducible RNA-releasing protein for translational regulation and optogenetic control of gene therapies. Trends Biotechnol, 2026
6. Photoactivated probiotic micro-reactor synchronizes STING/TLRs agonists to spatiotemporally synergize antitumor immunotherapy. J Nanobiotechnology, 2026
7. Light-directed evolution of dynamic, multi-state, and computational protein functionalities. Cell, 2026
8. Magneto-Photonic Gene Circuit for Minimally Invasive Control of Gene Expression in Mammalian Cells. ACS Omega, 2026
9. Improving T cell expansion by optogenetically engineered bacteria-loaded MMP-2-responsive cyclophosphamide for antitumor immunotherapy. J Nanobiotechnology, 2025
10. Magneto-Photonic Gene Circuit for Minimally Invasive Control of Gene Expression in Mammalian Cells. bioRxiv, 2025
11. De novo designed protein guiding targeted protein degradation. Nat Commun, 2025
12. Potent optogenetic regulation of gene expression in mammalian cells for bioproduction and basic research. Nucleic Acids Res, 2025
13. Orthogonal replication with optogenetic selection evolves yeast JEN1 into a mevalonate transporter. Mol Syst Biol, 2025
14. Balancing Doses of EL222 and Light Improves Optogenetic Induction of Protein Production in Komagataella phaffii. Biotechnol Bioeng, 2025
15. Optogenetic control of pheromone gradients and mating behavior in budding yeast. Life Sci Alliance, 2025
16. Light-induced expression of gRNA allows for optogenetic gene editing of T lymphocytes in vivo. Nucleic Acids Res, 2025
17. Anti-Pdc1p Nanobody as a Genetically Encoded Inhibitor of Ethanol Production Enables Dual Transcriptional and Post-translational Controls of Yeast Fermentations. ACS Synth Biol, 2025
18. Light-induced programmable solid-liquid phase transition of biomolecular condensates for improved biosynthesis. Trends Biotechnol, 2025
19. Functional analysis of Saccharomyces cerevisiae FLO genes through optogenetic control. FEMS Yeast Res, 2025
20. Optogenetic control of transgene expression in Marchantia polymorpha. Appl Plant Sci, 2025
21. Optogenetic control of Corynebacterium glutamicum gene expression. Nucleic Acids Res, 2024
22. Genetically-stable engineered optogenetic gene switches modulate spatial cell morphogenesis in two- and three-dimensional tissue cultures. Nat Commun, 2024
23. Light-Induced Nanobody-Mediated Targeted Protein Degradation for Metabolic Flux Control. ACS Synth Biol, 2024
24. Bacteria-based cascade in situ near-infrared nano-optogenetically induced photothermal tumor therapy. Theranostics, 2024
25. Optogenetic control of phosphate-responsive genes using single component fusion proteins in Saccharomyces cerevisiae. bioRxiv, 2024
26. Multisite Assembly of Gateway Induced Clones (MAGIC): a flexible cloning toolbox with diverse applications in vertebrate model systems. bioRxiv, 2024
27. Dynamic Multiplexed Control and Modeling of Optogenetic Systems Using the High-Throughput Optogenetic Platform, Lustro. ACS Synth Biol, 2024
28. Multicolor optogenetics for regulating flux ratio of three glycolytic pathways using EL222 and CcaSR in Escherichia coli. Biotechnol Bioeng, 2023
29. Light induced expression of gRNA allows for optogenetic gene editing of T lymphocytes in vivo. bioRxiv, 2023
30. Diya – a universal light illumination platform for multiwell plate cultures. iScience, 2023
31. Multidimensional characterization of inducible promoters and a highly light-sensitive LOV-transcription factor. Nat Commun, 2023
32. A Bioluminescent Activity Dependent (BLADe) Platform for Converting Neuronal Activity to Photoreceptor Activation. bioRxiv, 2023
33. Optogenetic closed-loop feedback control of the unfolded protein response optimizes protein production. Metab Eng, 2023
34. Light inducible protein degradation in E. coli with LOVtag. bioRxiv, 2023
35. Optogenetic control of beta-carotene bioproduction in yeast across multiple lab-scales. Front Bioeng Biotechnol, 2023
36. Near-Infrared Nano-Optogenetic Activation of Cancer Immunotherapy via Engineered Bacteria. Adv Mater, 2022
37. A Single-Component Blue Light-Induced System Based on EL222 in Yarrowia lipolytica. Int J Mol Sci, 2022
38. Hydrogel microcapsules containing engineered bacteria for sustained production and release of protein drugs. Biomaterials, 2022
39. Synthetic cells with self-activating optogenetic proteins communicate with natural cells. Nat Commun, 2022
40. Synthetic gene networks recapitulate dynamic signal decoding and differential gene expression. Cell Syst, 2022
41. Using single-cell models to predict the functionality of synthetic circuits at the population scale. Proc Natl Acad Sci U S A, 2022
42. Systematic In Vivo Characterization of Fluorescent Protein Maturation in Budding Yeast. ACS Synth Biol, 2022
43. Development of Optogenetic Dual-Switch System for Rewiring Metabolic Flux for Polyhydroxybutyrate Production. Molecules, 2022
44. Design and Characterization of an Optogenetic System in Pichia pastoris. ACS Synth Biol, 2022
45. A light tunable differentiation system for the creation and control of consortia in yeast. Nat Commun, 2021
46. Rapid prototyping and design of cybergenetic single-cell controllers. Nat Commun, 2021
47. Light-Induced GFP Expression in Zebrafish Embryos using the Optogenetic TAEL/C120 System. J Vis Exp, 2021
48. The Neurospora crassa Inducible Q System Enables Simultaneous Optogenetic Amplification and Inversion in Saccharomyces cerevisiae for Bidirectional Control of Gene Expression. ACS Synth Biol, 2021
49. Cellulosic biofuel production using emulsified simultaneous saccharification and fermentation (eSSF) with conventional and thermotolerant yeasts. Biotechnol Biofuels, 2021
50. Engineered NIR light-responsive bacteria as anti-tumor agent for targeted and precise cancer therapy. Lancet Infect Dis, 2021
51. Optogenetic Amplification Circuits for Light-Induced Metabolic Control. ACS Synth Biol, 2021
52. Blue Light‐Operated CRISPR/Cas13b‐Mediated mRNA Knockdown (Lockdown). Adv Biol, 2021
53. TAEL 2.0: An Improved Optogenetic Expression System for Zebrafish. Zebrafish, 2021
54. Dynamical Modeling of Optogenetic Circuits in Yeast for Metabolic Engineering Applications. ACS Synth Biol, 2021
55. Optogenetics in Sinorhizobium meliloti Enables Spatial Control of Exopolysaccharide Production and Biofilm Structure. ACS Synth Biol, 2021
56. An Optogenetic Platform to Dynamically Control the Stiffness of Collagen Hydrogels. ACS Biomater Sci Eng, 2020
57. Engineering an Optogenetic CRISPRi Platform for Improved Chemical Production. ACS Synth Biol, 2020
58. An Irf6-Esrp1/2 regulatory axis controls midface morphogenesis in vertebrates. Development, 2020
59. Design and Characterization of Rapid Optogenetic Circuits for Dynamic Control in Yeast Metabolic Engineering. ACS Synth Biol, 2020
60. Optogenetic Downregulation of Protein Levels to Control Programmed Cell Death in Mammalian Cells with a Dual Blue-Light Switch. Methods Mol Biol, 2020
61. Optogenetic control of gene expression in plants in the presence of ambient white light. Nat Methods, 2020
62. Light-powered Escherichia coli cell division for chemical production. Nat Commun, 2020
63. Blue Light-Directed Cell Migration, Aggregation, and Patterning. J Mol Biol, 2020
64. Optical induction of autophagy via Transcription factor EB (TFEB) reduces pathological tau in neurons. PLoS ONE, 2020
65. Cell-in-the-loop pattern formation with optogenetically emulated cell-to-cell signaling. Nat Commun, 2020
66. An Open-Source Plate Reader. Biochemistry, 2018
67. Programming the Dynamic Control of Bacterial Gene Expression with a Chimeric Ligand- and Light-Based Promoter System. ACS Synth Biol, 2018
68. Dual-controlled optogenetic system for the rapid down-regulation of protein levels in mammalian cells. Sci Rep, 2018
69. Pulsatile inputs achieve tunable attenuation of gene expression variability and graded multi-gene regulation. Nat Commun, 2018
70. An Optogenetic Platform for Real-Time, Single-Cell Interrogation of Stochastic Transcriptional Regulation. Mol Cell, 2018
71. Cell-free optogenetic gene expression system. ACS Synth Biol, 2018
72. Optogenetic regulation of engineered cellular metabolism for microbial chemical production. Nature, 2018
73. A calcium- and light-gated switch to induce gene expression in activated neurons. Nat Biotechnol, 2017
74. TAEL: a zebrafish-optimized optogenetic gene expression system with fine spatial and temporal control. Development, 2016
75. Blue light-mediated transcriptional activation and repression of gene expression in bacteria. Nucleic Acids Res, 2016
76. An optogenetic gene expression system with rapid activation and deactivation kinetics. Nat Chem Biol, 2014
77. Blue light-induced dimerization of a bacterial LOV-HTH DNA-binding protein. Biochemistry, 2013
78. Blue light-mediated gene expression as a promising strategy to reduce antibiotic resistance in Escherichia coli. Biotechnol J, 2024
79. Construction and Characterization of Light-Responsive Transcriptional Systems. Methods Mol Biol, 2024