CRY2/CIB1

Related original publications

1. Temporal and spatial control of phosphatidylinositides using optogenetics ameliorates behavioral deficits in an Alzheimer's disease mouse model. Commun Biol, 2026
2. PIP2 stabilizes NaV1.5 gating and links receptor signaling to cardiac late sodium current. bioRxiv, 2026
3. Adhesion-driven rigidity transition decoupled from density-driven jamming triggers epithelial organization in embryonic tissues. Nat Phys, 2026
4. An Integrated Method for Photothrombotic Stroke Modeling and In Vivo Optrode Recording of Neuronal and Astrocytic Activity in Behaving Mice. J Vis Exp, 2026
5. Engineered Optogenetic Circuits In Yeast with Self-Sustained Outputs. Adv Sci (Weinh), 2026
6. Global impact on metabolic capacity of yeast cell factories by optogenetic control of the cAMP-PKA axis. Appl Environ Microbiol, 2026
7. Target degradation of CASPASE-1 for alleviation of inflammation in sepsis via optogenetically engineered extracellular vesicles. Acta Pharm Sin B, 2026
8. Tissue rigidity phase transition shapes morphogen gradients. Nat Cell Biol, 2026
9. An extracellular, optogenetic antibody platform for stimulus-gated antigen recognition and modulation of cell behavior. Cell Chem Biol, 2026
10. Characterization of a cofilin mutant with high actin bundling activity in living cells. bioRxiv, 2026
11. Photoactivatable CRISPR/Cas13d via upconversion nanoparticles for deep tissue RNA engineering and orthopedic therapy. Nat Commun, 2026
12. Epigenome regulators imbue a single eukaryotic promoter with diverse gene expression dynamics. iScience, 2026
13. Rationally designed light-inducible RNA-releasing protein for translational regulation and optogenetic control of gene therapies. Trends Biotechnol, 2026
14. STIM1 and endoplasmic reticulum-plasma membrane contact sites oscillate independently of calcium-induced calcium release. Open Biol, 2026
15. Myosin II-driven contractions of supporting cap cells promote sensory adaptation of Drosophila proprioceptors. Curr Biol, 2026
16. Optogenetic activation of TGFβ signaling drives ligand-free chondrogenesis in hESC-derived MSCs. Stem Cells, 2026
17. OptoLoop - an optogenetic tool to probe the functional role of genome organization. J Cell Sci, 2026
18. An orthogonal CRISPR/Cpf1 platform for precise spatiotemporal gene regulation and osteoporotic fracture repair. Cell Rep Methods, 2026
19. Novel GαGTP Sensors Reveal Endogenous and Subcellular G Protein Signaling Dynamics. bioRxiv, 2026
20. Notch Signalling Plays a Role in Patterning the Ventral Mesoderm During Early Embryogenesis in Drosophila melanogaster. Int J Mol Sci, 2026
21. A Non-Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation. Adv Sci (Weinh), 2026
22. Dynamic control of Raf-ERK signaling modulates neuronal activity across biological scales. bioRxiv, 2026
23. Membrane editing with proximity labeling reveals regulators of lipid homeostasis. Nat Chem Biol, 2026
24. The membrane transition strongly enhances biopolymer condensation through prewetting. Nat Chem Biol, 2026
25. Optogenetic engineering of BAX to control mitochondrial permeabilization and attenuate apoptosis in cells. Exp Mol Med, 2025
26. Rapid Optimization of a Light-Inducible System to Control Mammalian Gene Expression. J Vis Exp, 2025
27. A single-component optogenetic toolkit for programmable control of microtubule. bioRxiv, 2025
28. Why epithelial cells collectively move against a traveling signal wave. Soft Matter, 2025
29. Modeling mechanochemical coupling in optogenetically activated cell layers. Biophys J, 2025
30. Endogenous OptoRhoGEFs reveal biophysical principles of epithelial tissue furrowing. Nat Commun, 2025
31. Chemogenetic and optogenetic strategies for spatiotemporal control of split-enzyme-based calcium recording. bioRxiv, 2025
32. Opto-p53: A light-controllable activation of p53 signaling pathway. Cell Struct Funct, 2025
33. A simplified two-plasmid system for orthogonal control of mammalian gene expression using light-activated CRISPR effector. BMC Biotechnol, 2025
34. Optogenetic perturbation of lipid droplet localization affects lipid metabolism and development in Drosophila. J Lipid Res, 2025
35. An Optical Approach to Modulating Membrane Protein Endocytosis Using a Light-Responsive Tag for Recruiting β-Arrestin. ACS Chem Biol, 2025
36. Red Light-Activated Reversible Inhibition of Protein Functions by Assembled Trap. ACS Synth Biol, 2025
37. In vivo regulation of an endogenously tagged protein by a light-regulated kinase. G3, 2025
38. Ferroptosis spreads to neighboring cells via plasma membrane contacts. Nat Commun, 2025
39. Light-induced expression of gRNA allows for optogenetic gene editing of T lymphocytes in vivo. Nucleic Acids Res, 2025
40. STIM1 and Endoplasmic Reticulum-Plasma Membrane Contact Sites Oscillate Independently of Calcium-Induced Calcium Release. bioRxiv, 2025
41. Talin, a Rap1 effector for integrin activation at the plasma membrane, also promotes Rap1 activity by disrupting sequestration of Rap1 by SHANK3. J Cell Sci, 2025
42. AGS3-based optogenetic GDI induces GPCR-independent Gβγ signalling and macrophage migration. Open Biol, 2025
43. Optogenetic control of Protein Kinase C-epsilon activity reveals its intrinsic signaling properties with spatiotemporal resolution. bioRxiv, 2025
44. Optogenetic control of mitochondrial aggregation and function. Front Bioeng Biotechnol, 2025
45. Light-dependent modulation of protein localization and function in living bacteria cells. Nat Commun, 2024
46. Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast. PLoS Biol, 2024
47. Src kinase slows collective rotation of confined epithelial cell monolayers. Soft Matter, 2024
48. Spatiotemporal control of subcellular O-GlcNAc signaling using Opto-OGT. Nat Chem Biol, 2024
49. Precise Control of Intracellular Trafficking and Receptor-Mediated Endocytosis in Living Cells and Behaving Animals. Adv Sci (Weinh), 2024
50. Optogenetic Control of the Mitochondrial Protein Import in Mammalian Cells. Cells, 2024
51. Precision in situ cryo-correlative light and electron microscopy of optogenetically-positioned organelles. J Cell Sci, 2024
52. Notch1 Phase Separation Coupled Percolation facilitates target gene expression and enhancer looping. Sci Rep, 2024
53. Atomistic mechanisms of the regulation of small-conductance Ca2+-activated K+ channel (SK2) by PIP2. Proc Natl Acad Sci U S A, 2024
54. PIP5K-Ras bistability initiates plasma membrane symmetry breaking to regulate cell polarity and migration. bioRxiv, 2024
55. Selective optogenetic inhibition of Gαq or Gαi signaling by minimal RGS domains disrupts circuit functionality and circuit formation. Proc Natl Acad Sci U S A, 2024
56. Phosphatidic acid is an endogenous negative regulator of PIEZO2 channels and mechanical sensitivity. Nat Commun, 2024
57. Optogenetic Strategies for Optimizing the Performance of Phospholipids Biosensors. Adv Sci (Weinh), 2024
58. Self-powered triboelectric-responsive microneedles with controllable release of optogenetically engineered extracellular vesicles for intervertebral disc degeneration repair. Nat Commun, 2024
59. Exploring plant-derived phytochrome chaperone proteins for light-switchable transcriptional regulation in mammals. Nat Commun, 2024
60. AGS3-based optogenetic GDI induces GPCR-independent Gβγ signaling and macrophage migration. bioRxiv, 2024
61. Spatiotemporal Control of Inflammatory Lytic Cell Death Through Optogenetic Induction of RIPK3 Oligomerization. J Mol Biol, 2024
62. Shaping an evanescent focus of light for high spatial resolution optogenetic activations in live cells. Opt Express, 2024
63. Liebig’s law of the minimum in the TGF-β/SMAD pathway. PLoS Comput Biol, 2024
64. Dynamic Multiplexed Control and Modeling of Optogenetic Systems Using the High-Throughput Optogenetic Platform, Lustro. ACS Synth Biol, 2024
65. Optogenetic control of Nodal signaling patterns. bioRxiv, 2024
66. Engineering Material Properties of Transcription Factor Condensates to Control Gene Expression in Mammalian Cells and Mice. Small, 2024
67. Using an ER-specific optogenetic mechanostimulator to understand the mechanosensitivity of the endoplasmic reticulum. Dev Cell, 2024
68. Temporal dynamics of BMP/Nodal ratio drive tissue-specific gastrulation morphogenesis. bioRxiv, 2024
69. Enhancing high-throughput optogenetics: Integration of LITOS with Lustro enables simultaneous light stimulation and shaking. MicroPubl Biol, 2024
70. Ultralow Background Membrane Editors for Spatiotemporal Control of Phosphatidic Acid Metabolism and Signaling ACS Cent Sci, 2024
71. Development of an optogenetics tool, Opto-RANK, for control of osteoclast differentiation using blue light. Sci Rep, 2024
72. A mechanical wave travels along a genetic guide to drive the formation of an epithelial furrow during Drosophila gastrulation. Dev Cell, 2024
73. A platform to induce and mature biomolecular condensates using chemicals and light. Nat Chem Biol, 2024
74. Engineered poly(A)-surrogates for translational regulation and therapeutic biocomputation in mammalian cells. Cell Res, 2024
75. Bidirectional Allosteric Coupling between PIP2 Binding and the Pore of the Oncochannel TRPV6. Int J Mol Sci, 2024
76. Optogenetic induction of caspase-8 mediated apoptosis by employing Arabidopsis cryptochrome 2. Sci Rep, 2023
77. Spatiotemporal Optical Control of Gαq-PLCβ Interactions. ACS Synth Biol, 2023
78. A single-component, light-assisted uncaging switch for endoproteolytic release. Nat Chem Biol, 2023
79. A programmable protease-based protein secretion platform for therapeutic applications. Nat Chem Biol, 2023
80. AAV-compatible optogenetic tools for activating endogenous calcium channels in vivo. Mol Brain, 2023
81. Light-activated BioID - an optically activated proximity labeling system to study protein-protein interactions. J Cell Sci, 2023
82. Spatiotemporal, optogenetic control of gene expression in organoids. Nat Methods, 2023
83. Photoactivatable base editors for spatiotemporally controlled genome editing in vivo. Biomaterials, 2023
84. Diya – a universal light illumination platform for multiwell plate cultures. iScience, 2023
85. Cell Cycle Control by Optogenetically Regulated Cell Cycle Inhibitor Protein p21. Biology (Basel), 2023
86. Force propagation between epithelial cells depends on active coupling and mechano-structural polarization. Elife, 2023
87. High-Throughput Optogenetics Experiments in Yeast Using the Automated Platform Lustro. J Vis Exp, 2023
88. Automatic detection of spatio-temporal signalling patterns in cell collectives. J Cell Biol, 2023
89. Tissue Flows Are Tuned by Actomyosin-Dependent Mechanics in Developing Embryos. PRX Life, 2023
90. Lustro: High-Throughput Optogenetic Experiments Enabled by Automation and a Yeast Optogenetic Toolkit. ACS Synth Biol, 2023
91. Optogenetic control of Cdc48 for dynamic metabolic engineering in yeast. Metab Eng, 2023
92. Concept and considerations of a medical device: the active noise cancelling incubator. Front Pediatr, 2023
93. An optogenetic-phosphoproteomic study reveals dynamic Akt1 signaling profiles in endothelial cells. Nat Commun, 2023
94. Optogenetic engineered umbilical cord MSC-derived exosomes for remodeling of the immune microenvironment in diabetic wounds and the promotion of tissue repair. J Nanobiotechnology, 2023
95. Activity-based directed evolution of a membrane editor in mammalian cells. Nat Chem, 2023
96. Actuation of single downstream nodes in growth factor network steers immune cell migration. Dev Cell, 2023
97. Rab8, Rab11, and Rab35 coordinate lumen and cilia formation during zebrafish left-right organizer development. PLoS Genet, 2023
98. OptIC Notch reveals mechanism that regulates receptor interactions with CSL. Development, 2023
99. Directed differentiation of human iPSCs into mesenchymal lineages by optogenetic control of TGF-β signaling. Cell Rep, 2023
100. Optogenetic inhibition of Gα signalling alters and regulates circuit functionality and early circuit formation. bioRxiv, 2023
101. Optogenetic Inhibition of Rho1-Mediated Actomyosin Contractility Coupled with Measurement of Epithelial Tension in Drosophila Embryos. J Vis Exp, 2023
102. Optogenetic decoding of Akt2-regulated metabolic signaling pathways in skeletal muscle cells using transomics analysis. Sci Signal, 2023
103. Light-driven biological actuators to probe the rheology of 3D microtissues. Nat Commun, 2023
104. Polarized branched Actin modulates cortical mechanics to produce unequal-size daughters during asymmetric division. Nat Cell Biol, 2023
105. Cell size and actin architecture determine force generation in optogenetically activated cells. Biophys J, 2023
106. An optogenetic tool to inhibit RhoA in Drosophila embryos. STAR Protoc, 2023
107. Golgi screen identifies the RhoGEF Solo as a novel regulator of RhoB and endocytic transport. Traffic, 2022
108. Rapid and reversible optogenetic silencing of synaptic transmission by clustering of synaptic vesicles. Nat Commun, 2022
109. An Optogenetic-Controlled Cell Reprogramming System for Driving Cell Fate and Light-Responsive Chimeric Mice. Adv Sci (Weinh), 2022
110. Regulation of EGF-stimulated activation of the PI-3K/AKT pathway by exocyst-mediated exocytosis. Proc Natl Acad Sci U S A, 2022
111. Patterned mechanical feedback establishes a global myosin gradient. Nat Commun, 2022
112. Mechanistic insights into cancer drug resistance through optogenetic PI3K signaling hyperactivation. Cell Chem Biol, 2022
113. Stable Transgenic Mouse Strain with Enhanced Photoactivatable Cre Recombinase for Spatiotemporal Genome Manipulation. Adv Sci (Weinh), 2022
114. Spatiotemporal dynamics of membrane surface charge regulates cell polarity and migration. Nat Cell Biol, 2022
115. Spatiotemporal control of ERK pulse frequency coordinates fate decisions during mammary acinar morphogenesis. Dev Cell, 2022
116. Optogenetic manipulation of cell migration with high spatiotemporal resolution using lattice lightsheet microscopy. Commun Biol, 2022
117. LITOS: a versatile LED illumination tool for optogenetic stimulation. Sci Rep, 2022
118. Light-activated mitochondrial fission through optogenetic control of mitochondria-lysosome contacts. Nat Commun, 2022
119. Optical regulation of endogenous RhoA reveals selection of cellular responses by signal amplitude. Cell Rep, 2022
120. Microtubule disassembly by caspases is an important rate-limiting step of cell extrusion. Nat Commun, 2022
121. Spindle reorientation in response to mechanical stress is an emergent property of the spindle positioning mechanisms. Proc Natl Acad Sci U S A, 2022
122. Precise control of microtubule disassembly in living cells. EMBO J, 2022
123. Transcription activation is enhanced by multivalent interactions independent of phase separation. Mol Cell, 2022
124. Light-induced fermenter production of derivatives of the sweet protein monellin is maximized in prestationary Saccharomyces cerevisiae cultures. Biotechnol J, 2022
125. Cell division in tissues enables macrophage infiltration. Science, 2022
126. Upregulated flotillins and sphingosine kinase 2 derail AXL vesicular traffic to promote epithelial-mesenchymal transition. J Cell Sci, 2022
127. An optogenetic tool to recruit individual PKC isozymes to the cell surface and promote specific phosphorylation of membrane proteins. J Biol Chem, 2022
128. Optogenetic Control of PIP2 Interactions Shaping ENaC Activity. Int J Mol Sci, 2022
129. The cell polarity determinant Dlg1 facilitates epithelial invagination by promoting tissue-scale mechanical coordination. Development, 2022
130. Synthetic gene networks recapitulate dynamic signal decoding and differential gene expression. Cell Syst, 2022
131. Optogenetic inhibition of actomyosin reveals mechanical bistability of the mesoderm epithelium during Drosophila mesoderm invagination. Elife, 2022
132. Optogenetic control of RNA function and metabolism using engineered light-switchable RNA-binding proteins. Nat Biotechnol, 2022
133. CeLINC, a fluorescence-based protein-protein interaction assay in Caenorhabditis elegans. Genetics, 2021
134. Optogenetic relaxation of actomyosin contractility uncovers mechanistic roles of cortical tension during cytokinesis. Nat Commun, 2021
135. Nano-optogenetic engineering of CAR T cells for precision immunotherapy with enhanced safety. Nat Nanotechnol, 2021
136. Cell patterning by secretion-induced plasma membrane flows. Sci Adv, 2021
137. An active tethering mechanism controls the fate of vesicles. Nat Commun, 2021
138. Revisiting the Role of TGFβ Receptor Internalization for Smad Signaling: It is Not Required in Optogenetic TGFβ Signaling Systems. Adv Biol (Weinh), 2021
139. Mechanical competition alters the cellular interpretation of an endogenous genetic programme. J Cell Biol, 2021
140. Optogenetic Tools for Control of Public Goods in Saccharomyces cerevisiae. mSphere, 2021
141. Mapping the dynamic transfer functions of eukaryotic gene regulation. Cell Syst, 2021
142. Using optogenetics to link myosin patterns to contractile cell behaviors during convergent extension. Biophys J, 2021
143. Light-inducible deformation of mitochondria in live cells. Cell Chem Biol, 2021
144. Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival. Dev Cell, 2021
145. Exosome-based delivery of super-repressor IκBα ameliorates kidney ischemia-reperfusion injury. Kidney Int, 2021
146. Optogenetic Control of the Canonical Wnt Signaling Pathway During Xenopus laevis Embryonic Development. J Mol Biol, 2021
147. Random sub-diffusion and capture of genes by the nuclear pore reduces dynamics and coordinates inter-chromosomal movement. Elife, 2021
148. PIP2 regulation of TRPC5 channel activation and desensitization. J Biol Chem, 2021
149. Optogenetic-based Localization of Talin to the Plasma Membrane Promotes Activation of β3 Integrins. J Biol Chem, 2021
150. A modular tool to query and inducibly disrupt biomolecular condensates. Nat Commun, 2021
151. A single-chain and fast-responding light-inducible Cre recombinase as a novel optogenetic switch. Elife, 2021
152. CRISPR-dcas9 Optogenetic Nanosystem for the Blue Light-Mediated Treatment of Neovascular Lesions. ACS Appl Bio Mater, 2021
153. Transient light-activated gene expression in Chinese hamster ovary cells. BMC Biotechnol, 2021
154. A CRISPR-Cas9-Based Near-Infrared Upconversion-Activated DNA Methylation Editing System. ACS Appl Mater Interfaces, 2021
155. A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice. Nat Commun, 2021
156. Control of SRC molecular dynamics encodes distinct cytoskeletal responses by specifying signaling pathway usage. J Cell Sci, 2021
157. Optogenetic control of small GTPases reveals RhoA mediates intracellular calcium signaling. J Biol Chem, 2021
158. Living materials with programmable functionalities grown from engineered microbial co-cultures. Nat Mater, 2021
159. A Light-Inducible Split-dCas9 System for Inhibiting the Progression of Bladder Cancer Cells by Activating p53 and E-cadherin. Front Mol Biosci, 2021
160. Liquid-liquid phase separation of light-inducible transcription factors increases transcription activation in mammalian cells and mice. Sci Adv, 2021
161. Efficient photoactivatable Dre recombinase for cell type-specific spatiotemporal control of genome engineering in the mouse. Proc Natl Acad Sci U S A, 2020
162. Increased lateral tension is sufficient for epithelial folding in Drosophila. Development, 2020
163. Single-Protein Tracking to Study Protein Interactions During Integrin-Based Migration. Methods Mol Biol, 2020
164. Multichromatic Control of Signaling Pathways in Mammalian Cells. Adv Biosyst, 2020
165. Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila. Elife, 2020
166. Control of Cell Migration Using Optogenetics. Methods Mol Biol, 2020
167. Activation of Cdc42 GTPase upon CRY2-Induced Cortical Recruitment Is Antagonized by GAPs in Fission Yeast. Cells, 2020
168. CL6mN: Rationally Designed Optogenetic Photoswitches with Tunable Dissociation Dynamics. ACS Synth Biol, 2020
169. A non-invasive far-red light-induced split-Cre recombinase system for controllable genome engineering in mice. Nat Commun, 2020
170. Photo-SNAP-tag, a Light-Regulated Chemical Labeling System. ACS Chem Biol, 2020
171. Optogenetic Control of Gene Expression Using Cryptochrome 2 and a Light-Activated Degron. Methods Mol Biol, 2020
172. βH-spectrin is required for ratcheting apical pulsatile constrictions during tissue invagination. EMBO Rep, 2020
173. Early But Not Delayed Optogenetic RAF Activation Promotes Astrocytogenesis in Mouse Neural Progenitors. J Mol Biol, 2020
174. Photoactivatable RNA N6 -Methyladenosine Editing with CRISPR-Cas13. Small, 2020
175. Dual Function of PI(4,5)P2 in Insulin-Regulated Exocytic Trafficking of GLUT4 in Adipocytes. J Mol Biol, 2020
176. ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization. Dev Cell, 2020
177. CofActor: A light- and stress-gated optogenetic clustering tool to study disease-associated cytoskeletal dynamics in living cells. J Biol Chem, 2020
178. Optical Activation of TrkB Signaling. J Mol Biol, 2020
179. CLIC4 is a cytokinetic cleavage furrow protein that regulates cortical cytoskeleton stability during cell division. J Cell Sci, 2020
180. Photoactivatable Cre recombinase 3.0 for in vivo mouse applications. Nat Commun, 2020
181. Optogenetic stimulation of phosphoinositides reveals a critical role of primary cilia in eye pressure regulation. Sci Adv, 2020
182. Phosphatidylinositol 4,5-bisphosphate directly interacts with the β and γ subunits of the sodium channel ENaC. J Biol Chem, 2020
183. Exosome-based delivery of super-repressor IκBα relieves sepsis-associated organ damage and mortality. Sci Adv, 2020
184. A Generalizable Optogenetic Strategy to Regulate Receptor Tyrosine Kinases during Vertebrate Embryonic Development. J Mol Biol, 2020
185. Cytokinetic bridge triggers de novo lumen formation in vivo. Nat Commun, 2020
186. Tissue-Scale Mechanical Coupling Reduces Morphogenetic Noise to Ensure Precision during Epithelial Folding. Dev Cell, 2020
187. Spatiotemporal control of phosphatidic acid signaling with optogenetic, engineered phospholipase Ds. J Cell Biol, 2020
188. Mps1-mediated release of Mad1 from nuclear pores ensures the fidelity of chromosome segregation. J Cell Biol, 2020
189. Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling. Nat Commun, 2020
190. Engineering light-controllable CAR T cells for cancer immunotherapy. Sci Adv, 2020
191. Pulsatile MAPK Signaling Modulates p53 Activity to Control Cell Fate Decisions at the G2 Checkpoint for DNA Damage. Cell Rep, 2020
192. Optogenetic control of mRNA localization and translation in live cells. Nat Cell Biol, 2020
193. Cell and tissue manipulation with ultrashort infrared laser pulses in light-sheet microscopy. Sci Rep, 2020
194. Optogenetics reveals Cdc42 local activation by scaffold-mediated positive feedback and Ras GTPase. PLoS Biol, 2020
195. Shape-morphing living composites. Sci Adv, 2020
196. Tunable light and drug induced depletion of target proteins. Nat Commun, 2020
197. Stick-slip dynamics of cell adhesion triggers spontaneous symmetry breaking and directional migration of mesenchymal cells on one-dimensional lines. Sci Adv, 2020
198. Engineered BRET-Based Biologic Light Sources Enable Spatiotemporal Control over Diverse Optogenetic Systems. ACS Synth Biol, 2019
199. Primary Cilia Signaling Promotes Axonal Tract Development and Is Disrupted in Joubert Syndrome-Related Disorders Models. Dev Cell, 2019
200. Directed evolution improves the catalytic efficiency of TEV protease. Nat Methods, 2019
201. Blue light-triggered optogenetic system for treating uveal melanoma. Oncogene, 2019
202. A yeast optogenetic toolkit (yOTK) for gene expression control in Saccharomyces cerevisiae. Biotechnol Bioeng, 2019
203. Optogenetic inhibition of Delta reveals digital Notch signaling output during tissue differentiation. EMBO Rep, 2019
204. Imaging of Morphological and Biochemical Hallmarks of Apoptosis with Optimized Optogenetic Actuators. PLoS ONE, 2019
205. Flotillins promote T cell receptor sorting through a fast Rab5-Rab11 endocytic recycling axis. Nat Commun, 2019
206. Visualizing RNA dynamics in live cells with bright and stable fluorescent RNAs. Nat Biotechnol, 2019
207. FRET-assisted photoactivation of flavoproteins for in vivo two-photon optogenetics. Nat Methods, 2019
208. Secretory Vesicle Clustering in Fungal Filamentous Cells Does Not Require Directional Growth. Cell Rep, 2019
209. Light-Induced Transcription Activation for Time-Lapse Microscopy Experiments in Living Cells. Methods Mol Biol, 2019
210. Transient Activations of Rac1 at the Lamellipodium Tip Trigger Membrane Protrusion. Curr Biol, 2019
211. Optogenetic gene editing in regional skin. Cell Res, 2019
212. Achieving tight control of a photoactivatable Cre recombinase gene switch: new design strategies and functional characterization in mammalian cells and rodent. Nucleic Acids Res, 2019
213. Cross-linker-mediated regulation of actin network organization controls tissue morphogenesis. J Cell Biol, 2019
214. LADL: light-activated dynamic looping for endogenous gene expression control. Nat Methods, 2019
215. OpEn-Tag-A Customizable Optogenetic Toolbox To Dissect Subcellular Signaling. ACS Synth Biol, 2019
216. Self-Organized Nuclear Positioning Synchronizes the Cell Cycle in Drosophila Embryos. Cell, 2019
217. Cortical mitochondria regulate insulin secretion by local Ca2+ buffering. J Cell Sci, 2019
218. Advances in optogenetic regulation of gene expression in mammalian cells using cryptochrome 2 (CRY2). Methods, 2019
219. Optogenetic perturbation of the biochemical pathways that control cell behavior. Meth Enzymol, 2019
220. Design, construction, and validation of optogenetic proteins. Lancet Diabetes Endocrinol, 2019
221. Physical Plasma Membrane Perturbation Using Subcellular Optogenetics Drives Integrin-Activated Cell Migration. ACS Synth Biol, 2019
222. Light-Induced Protein Clustering for Optogenetic Interference and Protein Interaction Analysis in Drosophila S2 Cells. Biomolecules, 2019
223. Near-infrared light remotely up-regulate autophagy with spatiotemporal precision via upconversion optogenetic nanosystem. Biomaterials, 2019
224. A Photoactivatable Botulinum Neurotoxin for Inducible Control of Neurotransmission. Neuron, 2019
225. Noninvasive optical activation of Flp recombinase for genetic manipulation in deep mouse brain regions. Nat Commun, 2019
226. Blue Light Switchable Cell–Cell Interactions Provide Reversible and Spatiotemporal Control Towards Bottom-Up Tissue Engineering. Adv Biosyst, 2019
227. Enhanced intrinsic CYP3A4 activity in human hepatic C3A cells with optically controlled CRISPR/dCas9 activator complex. Integr Biol (Camb), 2018
228. Optogenetic dissection of Rac1 and Cdc42 gradient shaping. Nat Commun, 2018
229. Downregulation of basal myosin-II is required for cell shape changes and tissue invagination. EMBO J, 2018
230. Membrane dynamics induced by a PIP3 optogenetic tool. Anal Sci, 2018
231. Real-Time Genetic Compensation Defines the Dynamic Demands of Feedback Control. Cell, 2018
232. RalB directly triggers invasion downstream Ras by mobilizing the Wave complex. Elife, 2018
233. Light Control of the Tet Gene Expression System in Mammalian Cells. Cell Rep, 2018
234. Optogenetic control of epithelial-mesenchymal transition in cancer cells. Sci Rep, 2018
235. A Single-Component Optogenetic System Allows Stringent Switch of Gene Expression in Yeast Cells. ACS Synth Biol, 2018
236. Spatiotemporal control of zebrafish (Danio rerio) gene expression using a light-activated CRISPR activation system. Gene, 2018
237. Optical activation of TrkA signaling. ACS Synth Biol, 2018
238. Synthetic far-red light-mediated CRISPR-dCas9 device for inducing functional neuronal differentiation. Proc Natl Acad Sci USA, 2018
239. Guided morphogenesis through optogenetic activation of Rho signalling during early Drosophila embryogenesis. Nat Commun, 2018
240. Independent Control over Multiple Cell Types in Space and Time Using Orthogonal Blue and Red Light Switchable Cell Interactions. Adv Sci, 2018
241. A platform of BRET-FRET hybrid biosensors for optogenetics, chemical screening, and in vivo imaging. Sci Rep, 2018
242. Regulation of cell cycle progression by cell-cell and cell-matrix forces. Nat Cell Biol, 2018
243. Optogenetic inhibition of Gαq protein signaling reduces calcium oscillation stochasticity. ACS Synth Biol, 2018
244. A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation. Nat Commun, 2018
245. Analysis of the CaMKIIα and β splice-variant distribution among brain regions reveals isoform-specific differences in holoenzyme formation. Sci Rep, 2018
246. A biochemical network controlling basal myosin oscillation. Nat Commun, 2018
247. Optogenetic Control of Cell Migration. Methods Mol Biol, 2018
248. Light-activated protein interaction with high spatial subcellular confinement. Proc Natl Acad Sci USA, 2018
249. Generation of Optogenetically Modified Adenovirus Vector for Spatiotemporally Controllable Gene Therapy. ACS Chem Biol, 2018
250. Unique Roles of β-Arrestin in GPCR Trafficking Revealed by Photoinducible Dimerizers. Sci Rep, 2018
251. Spatiotemporal Control of TGF-β Signaling with Light. ACS Synth Biol, 2017
252. Gradients of Rac1 Nanoclusters Support Spatial Patterns of Rac1 Signaling. Cell Rep, 2017
253. Real-time observation of light-controlled transcription in living cells. J Cell Sci, 2017
254. Optogenetic regulation of artificial microRNA improves H2 production in green alga Chlamydomonas reinhardtii. Biotechnol Biofuels, 2017
255. Propagating Wave of ERK Activation Orients Collective Cell Migration. Dev Cell, 2017
256. Near-Infrared Light Triggered Upconversion Optogenetic Nanosystem for Cancer Therapy. ACS Nano, 2017
257. Design and Profiling of a Subcellular Targeted Optogenetic cAMP-Dependent Protein Kinase. Cell Chem Biol, 2017
258. Optimized light-inducible transcription in mammalian cells using Flavin Kelch-repeat F-box1/GIGANTEA and CRY2/CIB1. Nucleic Acids Res, 2017
259. A single-chain photoswitchable CRISPR-Cas9 architecture for light-inducible gene editing and transcription. ACS Chem Biol, 2017
260. Understanding CRY2 interactions for optical control of intracellular signaling. Nat Commun, 2017
261. CRISPR-Cas9-based photoactivatable transcription systems to induce neuronal differentiation. Nat Methods, 2017
262. Two independent but synchronized Gβγ subunit-controlled pathways are essential for trailing-edge retraction during macrophage migration. J Biol Chem, 2017
263. Photo-Activatable Akt Probe - A New Tool to Study the Akt-Dependent Physiopathology of Cancer Cells. Oncol Res, 2017
264. An Engineered Optogenetic Switch for Spatiotemporal Control of Gene Expression, Cell Differentiation, and Tissue Morphogenesis. ACS Synth Biol, 2017
265. Vesicle Docking Is a Key Target of Local PI(4,5)P2 Metabolism in the Secretory Pathway of INS-1 Cells. Cell Rep, 2017
266. A calcium- and light-gated switch to induce gene expression in activated neurons. Nat Biotechnol, 2017
267. Optogenetic activation of Plexin-B1 reveals contact repulsion between osteoclasts and osteoblasts. Nat Commun, 2017
268. Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development. J Vis Exp, 2017
269. Bidirectional approaches for optogenetic regulation of gene expression in mammalian cells using Arabidopsis cryptochrome 2. Nucleic Acids Res, 2017
270. Cell-matrix adhesion and cell-cell adhesion differentially control basal myosin oscillation and Drosophila egg chamber elongation. Nat Commun, 2017
271. Temporally precise labeling and control of neuromodulatory circuits in the mammalian brain. Nat Methods, 2017
272. Light-Regulated Protein Kinases Based on the CRY2-CIB1 System. Methods Mol Biol, 2017
273. Optogenetic control of cellular forces and mechanotransduction. Nat Commun, 2017
274. Epigenetic Editing of Ascl1 Gene in Neural Stem Cells by Optogenetics. Sci Rep, 2017
275. Optogenetic Control of Synaptic Composition and Function. Neuron, 2017
276. Transcription activator-like effector-mediated regulation of gene expression based on the inducible packaging and delivery via designed extracellular vesicles. Biochem Biophys Res Commun, 2017
277. A Photoactivatable Innate Immune Receptor for Optogenetic Inflammation. ACS Chem Biol, 2016
278. Plasma Membrane Association but Not Midzone Recruitment of RhoGEF ECT2 Is Essential for Cytokinesis. Cell Rep, 2016
279. Optogenetic inhibition of apical constriction during Drosophila embryonic development. Methods Cell Biol, 2016
280. An open-hardware platform for optogenetics and photobiology. Sci Rep, 2016
281. A photoactivatable Cre-loxP recombination system for optogenetic genome engineering. Nat Chem Biol, 2016
282. Reversible optogenetic control of kinase activity during differentiation and embryonic development. Development, 2016
283. Optogenetic regulation of site-specific subtelomeric DNA methylation. Oncotarget, 2016
284. Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein-protein interaction module. Nat Commun, 2016
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