DrBphP

Photoreceptor DrBphP
Binding partner /
Cofactor Biliverdin
Source organism Deinococcus radiodurans
Mode of action homodimerization, dissociation
Excitation wavelength 660 nm
Reversion wavelength 780 nm, dark
Excitation time ? Add information
Reversion time ? Add information
Crystal structure of DrBphP, Pr state. (PDB ID: 4O0P)

DrBphP-derived switches:

Related original publications

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  1. Optogenetics Methods and Protocols Methods Mol Biol, 2024
  2. A sensitive red/far-red photoswitch for controllable gene therapy in mouse models of metabolic diseases. Nat Commun, 2024
  3. Advanced deep-tissue imaging and manipulation enabled by biliverdin reductase knockout. bioRxiv, 2024
  4. Induction of bacterial expression at the mRNA level by light. Nucleic Acids Res, 2024
  5. Leveraging the histidine kinase-phosphatase duality to sculpt two-component signaling. Nat Commun, 2024
  6. Near-Infrared Optogenetic Module for Conditional Protein Splicing. J Mol Biol, 2023
  7. Optogenetic Control of Bacterial Expression by Red Light. ACS Synth Biol, 2022
  8. A red light-responsive photoswitch for deep tissue optogenetics. Nat Biotechnol, 2022
  9. A general approach for engineering RTKs optically controlled with far-red light. Nat Methods, 2022
  10. Benchmarking of Cph1 Mutants and DrBphP for Light-Responsive Phytochrome-Based Hydrogels with Reversibly Adjustable Mechanical Properties. Adv Biol (Weinh), 2022
  11. Changes in tongue-palatal contact during swallowing in patients with skeletal mandibular prognathism after orthognathic surgery. PLoS ONE, 2021
  12. Creating Red Light-Switchable Protein Dimerization Systems as Genetically Encoded Actuators with High Specificity. ACS Synth Biol, 2020
  13. Bacterial Phytochrome as a Scaffold for Engineering of Receptor Tyrosine Kinases Controlled with Near-Infrared Light. J Mol Biol, 2020
  14. Focusing light inside live tissue using reversibly switchable bacterial phytochrome as a genetically encoded photochromic guide star. Sci Adv, 2019
  15. Revisiting and Redesigning Light-Activated Cyclic-Mononucleotide Phosphodiesterases. J Mol Biol, 2019
  16. Neurotrophin receptor tyrosine kinases regulated with near-infrared light. Nat Commun, 2019
  17. Structure-guided design and functional characterization of an artificial red light-regulated guanylate/adenylate cyclase for optogenetic applications. J Biol Chem, 2018
  18. Multimodal Control of Bacterial Gene Expression by Red and Blue Light. Methods Mol Biol, 2024