Magnets

Photoreceptor pMag, nMag
Binding partner /
Cofactor FAD
Source organism Neurospora crassa
Mode of action heterodimerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time seconds to hours (variants available)

Related original publications

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  1. Complex optogenetic spatial patterning with split recombinase. bioRxiv, 2024
  2. In Vivo Optogenetics Based on Heavy Metal-Free Photon Upconversion Nanoparticles. Adv Mater, 2024
  3. Optogenetic control of early embryos labeling using photoactivatable Cre recombinase 3.0. FEBS Open Bio, 2024
  4. In vivo optogenetic manipulations of endogenous proteins reveal spatiotemporal roles of microtubule and kinesin in dendrite patterning. Sci Adv, 2024
  5. Dynamic Multiplexed Control and Modeling of Optogenetic Systems Using the High-Throughput Optogenetic Platform, Lustro. ACS Synth Biol, 2024
  6. Optogenetic Control of Bacterial Cell-Cell Adhesion Dynamics: Unraveling the Influence on Biofilm Architecture and Functionality. Adv Sci (Weinh), 2024
  7. Programmable RNA base editing with photoactivatable CRISPR-Cas13. Nat Commun, 2024
  8. Development of an optogenetic gene expression system in Lactococcus lactis using a split photoactivatable T7 RNA polymerase. bioRxiv, 2024
  9. Photoactivation of LOV domains with chemiluminescence. Chem Sci, 2023
  10. Design and Engineering of Light-Induced Base Editors Facilitating Genome Editing with Enhanced Fidelity. Adv Sci (Weinh), 2023
  11. A programmable protease-based protein secretion platform for therapeutic applications. Nat Chem Biol, 2023
  12. Comprehensive Screening of a Light-Inducible Split Cre Recombinase with Domain Insertion Profiling. ACS Synth Biol, 2023
  13. Spatiotemporal, optogenetic control of gene expression in organoids. Nat Methods, 2023
  14. Photoactivatable base editors for spatiotemporally controlled genome editing in vivo. Biomaterials, 2023
  15. Diya – a universal light illumination platform for multiwell plate cultures. iScience, 2023
  16. High-Throughput Optogenetics Experiments in Yeast Using the Automated Platform Lustro. J Vis Exp, 2023
  17. Opto-RhoGEFs, an optimized optogenetic toolbox to reversibly control Rho GTPase activity on a global to subcellular scale, enabling precise control over vascular endothelial barrier strength. Elife, 2023
  18. Lustro: High-Throughput Optogenetic Experiments Enabled by Automation and a Yeast Optogenetic Toolkit. ACS Synth Biol, 2023
  19. A non-invasive photoactivatable split-Cre recombinase system for genome engineering in zebrafish. bioRxiv, 2023
  20. Synthetic Frizzled agonist and LRP antagonist for high-efficiency Wnt/β-catenin signaling manipulation in organoid cultures and in vivo. bioRxiv, 2023
  21. Detecting Photoactivatable Cre-mediated Gene Deletion Efficiency in Escherichia coli. Bio Protoc, 2023
  22. Generation of a photocontrollable recombinant bovine parainfluenza virus type 3. Microbiol Immunol, 2023
  23. Enhancing the performance of Magnets photosensors through directed evolution. bioRxiv, 2022
  24. Stable Transgenic Mouse Strain with Enhanced Photoactivatable Cre Recombinase for Spatiotemporal Genome Manipulation. Adv Sci (Weinh), 2022
  25. Blue Light Signaling Regulates Escherichia coli W1688 Biofilm Formation and l-Threonine Production. Microbiol Spectr, 2022
  26. Dynamic cybergenetic control of bacterial co-culture composition via optogenetic feedback. Nat Commun, 2022
  27. Implementation of a Novel Optogenetic Tool in Mammalian Cells Based on a Split T7 RNA Polymerase. ACS Synth Biol, 2022
  28. Optogenetic Maxwell Demon to Exploit Intrinsic Noise and Control Cell Differentiation Despite Time Delays and Extrinsic Variability. bioRxiv, 2022
  29. Biochemical noise enables a single optogenetic input to control identical cells to track asymmetric and asynchronous reference signals. bioRxiv, 2022
  30. Spatio-temporal, optogenetic control of gene expression in organoids. bioRxiv, 2022
  31. Rapid and robust optogenetic control of gene expression in Drosophila. Dev Cell, 2021
  32. Exploiting Noise, Non-Linearity, and Feedback for Differential Control of Multiple Synthetic Cells with a Single Optogenetic Input. ACS Synth Biol, 2021
  33. Repetitive short-pulsed illumination efficiently activates photoactivatable-Cre as continuous illumination in embryonic stem cells and pre-implantation embryos of transgenic mouse. Genesis, 2021
  34. Optogenetic Tools for Manipulating Protein Subcellular Localization and Intracellular Signaling at Organelle Contact Sites. Curr Protoc, 2021
  35. A single-chain and fast-responding light-inducible Cre recombinase as a novel optogenetic switch. Elife, 2021
  36. Efficient photoactivatable Dre recombinase for cell type-specific spatiotemporal control of genome engineering in the mouse. Proc Natl Acad Sci U S A, 2020
  37. Optimized Vivid-derived Magnets photodimerizers for subcellular optogenetics in mammalian cells. Elife, 2020
  38. Optogenetic regulation of embryo implantation in mice using photoactivatable CRISPR-Cas9. Proc Natl Acad Sci U S A, 2020
  39. Exploiting natural chemical photosensitivity of anhydrotetracycline and tetracycline for dynamic and setpoint chemo-optogenetic control. Nat Commun, 2020
  40. Bioluminescence-Triggered Photoswitchable Bacterial Adhesions Enable Higher Sensitivity and Dual-Readout Bacterial Biosensors for Mercury. ACS Sens, 2020
  41. Photoactivatable Cre recombinase 3.0 for in vivo mouse applications. Nat Commun, 2020
  42. Blue-Light-Switchable Bacterial Cell-Cell Adhesions Enable the Control of Multicellular Bacterial Communities. ACS Synth Biol, 2020
  43. Establishment of a tTA-dependent photoactivatable Cre recombinase knock-in mouse model for optogenetic genome engineering. Biochem Biophys Res Commun, 2020
  44. Light-Inducible Recombinases for Bacterial Optogenetics. ACS Synth Biol, 2020
  45. Engineered BRET-Based Biologic Light Sources Enable Spatiotemporal Control over Diverse Optogenetic Systems. ACS Synth Biol, 2019
  46. The importance of cell-cell interaction dynamics in bottom-up tissue engineering: Concepts of colloidal self-assembly in the fabrication of multicellular architectures. Nano Lett, 2019
  47. High-performance chemical- and light-inducible recombinases in mammalian cells and mice. Nat Commun, 2019
  48. Optogenetic activation of intracellular antibodies for direct modulation of endogenous proteins. Nat Methods, 2019
  49. An AND-Gated Drug and Photoactivatable Cre-loxP System for Spatiotemporal Control in Cell-Based Therapeutics. ACS Synth Biol, 2019
  50. Near-infrared optogenetic genome engineering based on photon upconversion hydrogels. Angew Chem Int Ed Engl, 2019
  51. A split CRISPR-Cpf1 platform for inducible genome editing and gene activation. Nat Chem Biol, 2019
  52. Photocontrollable mononegaviruses. Proc Natl Acad Sci USA, 2019
  53. Noninvasive optical activation of Flp recombinase for genetic manipulation in deep mouse brain regions. Nat Commun, 2019
  54. Reversible Social Self-Sorting of Colloidal Cell-Mimics with Blue Light Switchable Proteins. ACS Synth Biol, 2018
  55. Light-activated protein interaction with high spatial subcellular confinement. Proc Natl Acad Sci USA, 2018
  56. Optogenetic Control of Endoplasmic Reticulum-Mitochondria Tethering. ACS Synth Biol, 2017
  57. Dynamic Blue Light-Inducible T7 RNA Polymerases (Opto-T7RNAPs) for Precise Spatiotemporal Gene Expression Control. ACS Synth Biol, 2017
  58. CRISPR-Cas9-based photoactivatable transcription systems to induce neuronal differentiation. Nat Methods, 2017
  59. Blue Light Switchable Bacterial Adhesion as a Key Step toward the Design of Biofilms. ACS Synth Biol, 2017
  60. Assembly Domain-Based Optogenetic System for the Efficient Control of Cellular Signaling. ACS Synth Biol, 2017
  61. Engineered Photoactivatable Genetic Switches Based on the Bacterium Phage T7 RNA Polymerase. ACS Synth Biol, 2016
  62. Optical manipulation of the alpha subunits of heterotrimeric G proteins using photoswitchable dimerization systems. Sci Rep, 2016
  63. A photoactivatable Cre-loxP recombination system for optogenetic genome engineering. Nat Chem Biol, 2016
  64. Photoactivatable CRISPR-Cas9 for optogenetic genome editing. Nat Biotechnol, 2015
  65. Engineered pairs of distinct photoswitches for optogenetic control of cellular proteins. Nat Commun, 2015
  66. Optical Control of Genome Editing by Photoactivatable Cas9. Methods Mol Biol, 2021
  67. Optogenetic Activation of Intracellular Nanobodies. Methods Mol Biol, 2022
  68. Engineered Cas9 extracellular vesicles as a novel gene editing tool. J Extracell Vesicles, 2022
  69. Optical Control of Mononegavirus Gene Expression and Replication. Methods Mol Biol, 2024