PYP

Photoreceptor PYP
Binding partner /
Cofactor p-coumaric acid
Source organism Halorhodospira halophila
Mode of action intramolecular conformational change
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time seconds
Crystal structure of PYP, ground state. (PDB ID: 5HD3)

Related original publications

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  1. Photo-tunable hydrogels reveal cellular sensing of rapid rigidity changes through the accumulation of mechanical signaling molecules. Cell Stem Cell, 2024
  2. Structural and spectroscopic characterization of photoactive yellow protein and photoswitchable fluorescent protein constructs containing heavy atoms. J Photochem Photobiol A Chem, 2020
  3. Yeast Two Hybrid Screening of Photo-Switchable Protein-Protein Interaction Libraries. J Mol Biol, 2020
  4. A time-dependent role for the transcription factor CREB in neuronal allocation to an engram underlying a fear memory revealed using a novel in vivo optogenetic tool to modulate CREB function. Neuropsychopharmacology, 2019
  5. A yeast system for discovering optogenetic inhibitors of eukaryotic translation initiation. ACS Synth Biol, 2019
  6. Discovering selective binders for photoswitchable proteins using phage display. ACS Synth Biol, 2018
  7. Optogenetic Inhibitor of the Transcription Factor CREB. Chem Biol, 2015
  8. A photoswitchable DNA-binding protein based on a truncated GCN4-photoactive yellow protein chimera. Photochem Photobiol Sci, 2010