CRY2olig

Related original publications

1. PyCLM: programming-free, closed-loop microscopy for real-time measurement, segmentation, and optogenetic stimulation. bioRxiv, 2025
2. Activation of NF-κB Signaling by Optogenetic Clustering of IKKα and β. Adv Biol (Weinh), 2025
3. Optogenetics-enabled discovery of integrated stress response modulators. Cell, 2025
4. Membranes arrest the coarsening of mitochondrial condensates. bioRxiv, 2025
5. Combining light-induced aggregation and biotin proximity labeling implicates endolysosomal proteins in early α-synuclein oligomerization. iScience, 2025
6. Tau Oligomerization Drives Neurodegeneration via Nuclear Membrane Invagination and Lamin B Receptor Binding in Alzheimer’s disease. bioRxiv, 2025
7. Optogenetic induction of TDP-43 aggregation impairs neuronal integrity and behavior in Caenorhabditis elegans. Transl Neurodegener, 2025
8. POT, an optogenetics-based endogenous protein degradation system. Commun Biol, 2025
9. Large-scale control over collective cell migration using light-activated epidermal growth factor receptors. Cell Syst, 2025
10. Tubulin transforms Tau and α-synuclein condensates from pathological to physiological. bioRxiv, 2025
11. Inducing aggresome and stable tau aggregation in Neuro2a cells with an optogenetic tool. BPPB, 2024
12. Assays to measure small molecule Hsp70 agonist activity in vitro and in vivo. Anal Biochem, 2024
13. RNA G-quadruplexes form scaffolds that promote neuropathological α-synuclein aggregation. Cell, 2024
14. C9orf72 poly-PR forms anisotropic condensates causative of nuclear TDP-43 pathology. iScience, 2024
15. In vivo optogenetic manipulations of endogenous proteins reveal spatiotemporal roles of microtubule and kinesin in dendrite patterning. Sci Adv, 2024
16. Prior Fc receptor activation primes macrophages for increased sensitivity to IgG via long-term and short-term mechanisms. Dev Cell, 2024
17. Intracellular tau fragment droplets serve as seeds for tau fibrils. Structure, 2024
18. Spatiotemporal Control of Inflammatory Lytic Cell Death Through Optogenetic Induction of RIPK3 Oligomerization. J Mol Biol, 2024
19. Engineering Material Properties of Transcription Factor Condensates to Control Gene Expression in Mammalian Cells and Mice. Small, 2024
20. Optogenetic Regulation of EphA1 RTK Activation and Signaling. bioRxiv, 2024
21. A platform to induce and mature biomolecular condensates using chemicals and light. Nat Chem Biol, 2024
22. Optogenetic-mediated induction and monitoring of α-synuclein aggregation in cellular models of Parkinson's disease. STAR Protoc, 2023
23. Optogenetic Induction of Pyroptosis, Necroptosis, and Apoptosis in Mammalian Cell Lines. Bio Protoc, 2023
24. Optogenetic control of the integrated stress response reveals proportional encoding and the stress memory landscape. Cell Syst, 2023
25. The Opto-inflammasome in zebrafish as a tool to study cell and tissue responses to speck formation and cell death. Elife, 2023
26. Structural basis of NINJ1-mediated plasma membrane rupture in cell death. Nature, 2023
27. Integration of intermittent calcium signals in T cells revealed by temporally patterned optogenetics. iScience, 2023
28. DIAPH3 condensates formed by liquid-liquid phase separation act as a regulatory hub for stress-induced actin cytoskeleton remodeling. Cell Rep, 2023
29. Rapid and reversible optogenetic silencing of synaptic transmission by clustering of synaptic vesicles. Nat Commun, 2022
30. WNK kinases sense molecular crowding and rescue cell volume via phase separation. Cell, 2022
31. Optogenetic control of GGGGCC repeat-containing RNA phase transition. Fundam res, 2022
32. Optogenetic manipulation of cell migration with high spatiotemporal resolution using lattice lightsheet microscopy. Commun Biol, 2022
33. Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing. Nat Commun, 2022
34. PPARγ phase separates with RXRα at PPREs to regulate target gene expression. Cell Discov, 2022
35. Optogenetic activators of apoptosis, necroptosis, and pyroptosis. J Cell Biol, 2022
36. Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae. J Vis Exp, 2022
37. CeLINC, a fluorescence-based protein-protein interaction assay in Caenorhabditis elegans. Genetics, 2021
38. Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy. Mol Cell, 2021
39. Rac1 activation can generate untemplated, lamellar membrane ruffles. BMC Biol, 2021
40. A modular tool to query and inducibly disrupt biomolecular condensates. Nat Commun, 2021
41. Optogenetic manipulation of cellular communication using engineered myosin motors. Nat Cell Biol, 2021
42. The proline-rich domain promotes Tau liquid-liquid phase separation in cells. J Cell Biol, 2020
43. Nucleated transcriptional condensates amplify gene expression. Nat Cell Biol, 2020
44. Optogenetic TDP-43 nucleation induces persistent insoluble species and progressive motor dysfunction in vivo. Neurobiol Dis, 2020
45. Phosphofructokinase Relocalizes into Subcellular Compartments with Liquid-like Properties In Vivo. Biophys J, 2020
46. m6A-binding YTHDF proteins promote stress granule formation. Nat Chem Biol, 2020
47. Composition-dependent thermodynamics of intracellular phase separation. Nature, 2020
48. Nuclear actin regulates inducible transcription by enhancing RNA polymerase II clustering. Sci Adv, 2020
49. Optogenetic manipulation of calcium signals in single T cells in vivo. Nat Commun, 2020
50. Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons. Nat Commun, 2020
51. Non-invasive optical control of endogenous Ca2+ channels in awake mice. Nat Commun, 2020
52. Optogenetic inhibition of Delta reveals digital Notch signaling output during tissue differentiation. EMBO Rep, 2019
53. Controlling the material properties and rRNA processing function of the nucleolus using light. Proc Natl Acad Sci USA, 2019
54. Phase separation of 53BP1 determines liquid-like behavior of DNA repair compartments. EMBO J, 2019
55. LADL: light-activated dynamic looping for endogenous gene expression control. Nat Methods, 2019
56. Light-based control of metabolic flux through assembly of synthetic organelles. Nat Chem Biol, 2019
57. NF-κB signaling dynamics is controlled by a dose-sensing autoregulatory loop. Sci Signal, 2019
58. RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43. Neuron, 2019
59. Light-Induced Protein Clustering for Optogenetic Interference and Protein Interaction Analysis in Drosophila S2 Cells. Biomolecules, 2019
60. Increasing spatial resolution of photoregulated GTPases through immobilized peripheral membrane proteins. Small GTPases, 2018
61. Activation of EphB2 Forward Signaling Enhances Memory Consolidation. Cell Rep, 2018
62. Filopodia Conduct Target Selection in Cortical Neurons Using Differences in Signal Kinetics of a Single Kinase. Neuron, 2018
63. Analysis of the CaMKIIα and β splice-variant distribution among brain regions reveals isoform-specific differences in holoenzyme formation. Sci Rep, 2018
64. Optogenetic activation of EphB2 receptor in dendrites induced actin polymerization by activating Arg kinase. Biol Open, 2017
65. Understanding CRY2 interactions for optical control of intracellular signaling. Nat Commun, 2017
66. Optogenetic protein clustering through fluorescent protein tagging and extension of CRY2. Nat Commun, 2017
67. Optogenetic control of the Dab1 signaling pathway. Sci Rep, 2017
68. Spatiotemporal Control of Intracellular Phase Transitions Using Light-Activated optoDroplets. Cell, 2016
69. An optimized optogenetic clustering tool for probing protein interaction and function. Nat Commun, 2014
70. Gene Delivery and Analysis of Optogenetic Induction of Lytic Cell Death. Curr Protoc, 2024