CRY2clust

Photoreceptor CRY2clust
Binding partner /
Cofactor FAD
Source organism Arabidopsis thaliana
Mode of action homooligomerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time minutes

Related original publications

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  1. POT, an optogenetics-based endogenous protein degradation system. Commun Biol, 2025
  2. Optogenetic control of mitochondrial aggregation and function. Front Bioeng Biotechnol, 2025
  3. Mesoscale regulation of MTOCs by the E3 ligase TRIM37. bioRxiv, 2024
  4. Stress pathway outputs are encoded by pH-dependent clustering of kinase components. Nat Commun, 2024
  5. Spatiotemporal Control of Inflammatory Lytic Cell Death Through Optogenetic Induction of RIPK3 Oligomerization. J Mol Biol, 2024
  6. Protein supersaturation powers innate immune signaling. bioRxiv, 2024
  7. Development of an optogenetics tool, Opto-RANK, for control of osteoclast differentiation using blue light. Sci Rep, 2024
  8. Calcium transients trigger switch-like discharge of prostaglandin E2 in an extracellular signal-regulated kinase-dependent manner. Elife, 2024
  9. Optogenetic STING clustering system through nanobody-fused photoreceptor for innate immune regulation. Sens Actuators B Chem, 2023
  10. Visual quantification of prostaglandin E2 discharge from a single cell. Cell Struct Funct, 2023
  11. Optogenetic engineering of STING signaling allows remote immunomodulation to enhance cancer immunotherapy. Nat Commun, 2023
  12. Optogenetic control of the integrated stress response reveals proportional encoding and the stress memory landscape. Cell Syst, 2023
  13. Advanced human iPSC-based preclinical model for Parkinson's disease with optogenetic alpha-synuclein aggregation. Cell Stem Cell, 2023
  14. Light-activated macromolecular phase separation modulates transcription by reconfiguring chromatin interactions. Sci Adv, 2023
  15. A nucleation barrier spring-loads the CBM signalosome for binary activation. Elife, 2022
  16. Biophysical and biochemical properties of Deup1 self-assemblies: a potential driver for deuterosome formation during multiciliogenesis. Biol Open, 2021
  17. Non-invasive optical control of endogenous Ca2+ channels in awake mice. Nat Commun, 2020
  18. Flotillins promote T cell receptor sorting through a fast Rab5-Rab11 endocytic recycling axis. Nat Commun, 2019
  19. A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation. Nat Commun, 2018
  20. Optogenetic protein clustering through fluorescent protein tagging and extension of CRY2. Nat Commun, 2017
  21. Gene Delivery and Analysis of Optogenetic Induction of Lytic Cell Death. Curr Protoc, 2024