Curated Optogenetic Publication Database

Search precisely and efficiently by using the advantage of the hand-assigned publication tags that allow you to search for papers involving a specific trait, e.g. a particular optogenetic switch or a host organism.

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1.

Formation of nuclear condensates by the Mediator complex subunit Med15 in mammalian cells.

blue CRY2/CRY2 NIH/3T3 Organelle manipulation
BMC Biol, 17 Nov 2021 DOI: 10.1186/s12915-021-01178-y Link to full text
Abstract: The Mediator complex is an evolutionarily conserved multi-subunit protein complex that plays major roles in transcriptional activation and is essential for cell growth, proliferation, and differentiation. Recent studies revealed that some Mediator subunits formed nuclear condensates that may facilitate enhancer-promoter interactions and gene activation. The assembly, regulation, and functions of these nuclear condensates remain to be further understood.
2.

Rac1 activation can generate untemplated, lamellar membrane ruffles.

blue AsLOV2 CRY2olig HeLa hTERT RPE-1 Control of cytoskeleton / cell motility / cell shape
BMC Biol, 13 Apr 2021 DOI: 10.1186/s12915-021-00997-3 Link to full text
Abstract: Membrane protrusions that occur on the dorsal surface of a cell are an excellent experimental system to study actin machinery at work in a living cell. Small GTPase Rac1 controls the membrane protrusions that form and encapsulate extracellular volumes to perform pinocytic or phagocytic functions.
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