Curated Optogenetic Publication Database

Search precisely and efficiently by using the advantage of the hand-assigned publication tags that allow you to search for papers involving a specific trait, e.g. a particular optogenetic switch or a host organism.

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Circularly permuted AsLOV2 as an optogenetic module for engineering photoswitchable peptides.

blue AsLOV2 cpLOV2 iLID HEK293T S. cerevisiae
Chem Commun (Camb), 22 Jul 2021 DOI: 10.1039/d1cc02643g Link to full text
Abstract: We re-engineered a commonly-used light-sensing protein, AsLOV2, using a circular permutation strategy to allow photoswitchable control of the C-terminus of a peptide. We demonstrate that the circularly permuted AsLOV2 can be used on its own or together with the original AsLOV2 for enhanced caging. In summary, circularly permuted AsLOV2 could expand the engineering capabilities of optogenetic tools.
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