Curated Optogenetic Publication Database

Search precisely and efficiently by using the advantage of the hand-assigned publication tags that allow you to search for papers involving a specific trait, e.g. a particular optogenetic switch or a host organism.

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Optogenetic protein clustering and signaling activation in mammalian cells.

blue CRY2/CRY2 HEK293T NIH/3T3 Signaling cascade control Control of cytoskeleton / cell motility / cell shape
Nat Methods, 3 Feb 2013 DOI: 10.1038/nmeth.2360 Link to full text
Abstract: We report an optogenetic method based on Arabidopsis thaliana cryptochrome 2 for rapid and reversible protein oligomerization in response to blue light. We demonstrated its utility by photoactivating the β-catenin pathway, achieving a transcriptional response higher than that obtained with the natural ligand Wnt3a. We also demonstrated the modularity of this approach by photoactivating RhoA with high spatiotemporal resolution, thereby suggesting a previously unknown mode of activation for this Rho GTPase.
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