Curated Optogenetic Publication Database

Search precisely and efficiently by using the advantage of the hand-assigned publication tags that allow you to search for papers involving a specific trait, e.g. a particular optogenetic switch or a host organism.

Qr: host:"mouse in vivo"
Showing 101 - 102 of 102 results
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101.

Spatiotemporal control of gene expression by a light-switchable transgene system.

blue VVD HEK293 Hep G2 in vitro MCF7 MDA-MB-231 mouse in vivo PC-3 Transgene expression
Nat Methods, 12 Feb 2012 DOI: 10.1038/nmeth.1892 Link to full text
Abstract: We developed a light-switchable transgene system based on a synthetic, genetically encoded light-switchable transactivator. The transactivator binds promoters upon blue-light exposure and rapidly initiates transcription of target transgenes in mammalian cells and in mice. This transgene system provides a robust and convenient way to spatiotemporally control gene expression and can be used to manipulate many biological processes in living systems with minimal perturbation.
102.

Influence of a new virostatic compound on the induction of enzymes in rat liver.

blue CRY2/CIB1 EL222 HEK293FT HEK293T mouse in vivo primary mouse T cells Nucleic acid editing
Arzneimittelforschung, Sep 1975 DOI: 10.1093/nar/gkaf213 Link to full text
Abstract: The virostatic compound N,N-diethyl-4-[2-(2-oxo-3-tetradecyl-1-imidazolidinyl)-ethyl]-1-piperazinecarboxamide-hydrochloride (5531) was analyzed as to its effect on the induction of tryptophan-pyrrolase and tyrosineaminotransferase in rat liver. 1. The basic activity of the enzymes was not influenced by the substance either in normal or in adrenalectomized animals. 2. The induction of the enzymes by cortisone increased in the presence of the compound whereas the substrate induction remained unchanged. 3. The induction of tyrosine-aminotransferase by dexamethasonephosphate in tissue culture is inhibited if the dose of compound 5531 is higher than 5 mug/ml.
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